The South American zone's 2022 World Cup qualifiers had been scheduled to begin in late March but were postponed amid the escalating health crisis.
Alvaro Ordiozola will continue at right back after Dani Carvajal suffered a knee injury on Friday that will sideline him for a couple of months, while Ferland Mendy will likely return on the left after being rested in the narrow midweek win at home to Valladolid.
Al Nassr broke the deadlock with a penalty in the 35th minute before Abdi Mehdi Qara leveled for Persepolis just six minutes later.
But the 33-year-old soon after committed a serious foul on Leo Dubois, for which referee Stephanie Frappart initially showed a yellow card but changed it to a red after a VAR review.
The 31-year-old, who is to face No. 7 seed Petra Kvitova in the next match, also became the first Chinese singles player since Li Na in 2012 to reach the fourth round at Roland-Garros.
The Grand Prix Final had been scheduled for December 10-13, 2020 with the World Cup Short Track a week later. Both events were postponed "in consultation with all stakeholders and considering the pandemic developments," the ISU announced in a statement on Friday, with re-scheduling possibilities under discussion.
Growing infection figures around Cologne's venue are forcing Germany to play behind closed doors. Simultaneously, approval figures among German supporters decrease.
During the 18-round campaign, teams face lung-busting altitude, scorching tropical heat, long-haul flights between many cities and passionate fans that make stadiums such as Argentina's La Bombonera or Brazil's Maracana among the world's most inhospitable venues for opponents.
Serge Aurier added a fifth soon after the break, and a Kane penalty 10 minutes from time rounded off the scoring in a game that could leave Solskjaer's job at risk.
The world No. 4, and two-time finalist at Roland Garros in 2018 and 2019, reached the fourth round in Paris for the five consecutive years.
Vanderlei Luxemburgo's men are now third in the 20-team Serie A standings, just two points behind leader Atletico Mineiro, who has a game in hand.